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HPLC & LC-MS Grade Solvents

PRISTINE ultra-pure solvents for high-performance liquid chromatography and liquid chromatography-mass spectrometry, from Innovative Bioscience in Benicia, California. Low UV absorbance and low particulate counts, every lot supplied with a Certificate of Analysis. Browse the catalog below; the selection detail follows underneath.

Same-day shipping on orders placed before 2 PM PT

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How to choose

Three questions decide the solvent

Solvent selection comes down to the grade your detection needs, the solvent your method calls for, and the volume your throughput justifies.

1

HPLC or LC-MS grade

HPLC grade is specified for UV and standard chromatographic detection. LC-MS grade is held to tighter specifications for mass spectrometric detection, where trace contaminants raise background.

2

The solvent for the method

Acetonitrile, methanol, and water are the reversed-phase mobile-phase workhorses. Hexane, dichloromethane, and tetrahydrofuran cover normal-phase and stronger-eluent separations.

3

Bottle size

Solvents come in 1 L, 2.5 L, and 4 L bottle sizes. Match the size to method throughput and how quickly an opened bottle is consumed.

Compare the catalog

PRISTINE solvents by application

Innovative Bioscience carries seven PRISTINE ultra-pure solvents. Match the solvent to the separation, then choose grade and bottle size on the product page.

SolventCommon role
AcetonitrileThe standard organic mobile phase for reversed-phase HPLC and LC-MS
MethanolA reversed-phase mobile phase and a lower-cost alternative to acetonitrile for many methods
WaterThe aqueous component of reversed-phase mobile phases and sample diluent
Isopropyl alcoholA strong eluent and a common column-wash and storage solvent
DichloromethaneA normal-phase solvent and extraction solvent
TetrahydrofuranA strong eluent for difficult separations and gel-permeation chromatography
n-Hexane 95%A normal-phase mobile phase for non-polar separations

Purity and documentation

How the solvents are specified

  • Manufactured to meet or exceed ACS, HPLC, and LC-MS grade specifications
  • Low UV absorbance for a clean detection baseline
  • Low particulate counts for consistent chromatographic background
  • Every lot supplied with a Certificate of Analysis documenting purity, water content, UV cutoff, and particulate levels
  • Offered in 1 L, 2.5 L, and 4 L bottle sizes
  • Same-day shipping on orders placed before 2 PM PT, with case pricing for institutional buyers

Lot-to-lot consistency matters in analytical work because solvent background carries straight through to baseline, retention reproducibility, and mass spectrometric detection.

Common questions

Frequently asked questions

What is the difference between HPLC grade and LC-MS grade?

HPLC grade solvents are specified for UV and standard chromatographic detection. LC-MS grade solvents are held to tighter specifications because mass spectrometry is far more sensitive to trace contaminants, which raise background and suppress signal. Use LC-MS grade for any mass-spectrometric method.

Why does UV absorbance matter in a solvent?

The solvent forms the detection baseline. A solvent with low UV absorbance and a low UV cutoff lets you detect analytes cleanly at shorter wavelengths without the solvent itself contributing background.

What does the Certificate of Analysis document?

Every lot ships with a Certificate of Analysis recording purity, water content, UV cutoff, and particulate levels, so you can confirm the lot meets your method requirements before use.

What bottle sizes are available?

Solvents come in 1 L, 2.5 L, and 4 L bottle sizes. Smaller bottles limit exposure on lower-throughput methods; larger bottles reduce cost per liter for high-volume work.

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